Anti-inflammatory effect of MAPK phosphatase-1 local gene transfer in inflammatory bone loss
نویسندگان
چکیده
منابع مشابه
MAPK phosphatase-1 represents a novel anti-inflammatory target of glucocorticoids in the human endothelium.
Glucocorticoids are well-established anti-inflammatory drugs thought to mainly act by inhibition of proinflammatory transcription factors like NF-kappaB. In recent years, however, transcription factor-independent mechanisms of glucocorticoid action have been proposed, namely the influence on MAPK pathways. Here we identify MAPK phosphatase-1 (MKP-1) as a pivotal mediator of the anti-inflammator...
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Engagement of Toll-like receptors (TLRs) on macrophages leads to activation of the mitogen-activated protein kinases (MAPKs), which contribute to innate immune responses. MAPK activity is regulated negatively by MAPK phosphatases (MKPs). MKP-1, the founding member of this family of dual-specificity phosphatases, has been implicated in regulating lipopolysaccharide (LPS) responses, but its role ...
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ژورنال
عنوان ژورنال: Gene Therapy
سال: 2010
ISSN: 0969-7128,1476-5462
DOI: 10.1038/gt.2010.139